Inveon Multimodality SPECT Overview

The Inveon Multimodality scanner is configured with two SPECT detectors mounted coaxially on the same rotating stage as the CT source and detector. Each sodium iodide detector provides high count-rate performance and a wide dynamic range of 30-300 keV, which can be processed into multiple energy windows when imaging multiple isotopes. In the gantry, the rotating stage rotates 360º around the bed to acquire tomographic listmode data. When at home position, detector 1 is at 90º and detector 2 is at 270º. The SPECT detectors are mounted on a linear stage that enables them to move towards or away from the gantry’s isocenter in order to change the radius of rotation. There are 5 sets of mouse collimators, 3 sets of rat collimators, and 1 low energy all-purpose (LEAP) collimator that can be installed on each detector. This training describes the SPECT-specific graphic user interface (GUI) as well as how to configure SPECT protocols and workflows. Select Next to Continue. Course Objectives   Identify the components of the SPECT GUI   Setup and execute SPECT Protocols.   Setup and execute SPECT workflows.   Setup and execute SPECT/CT Workflows. Upon completion of this course you will be able to: You should now be able to: Identify the components of the SPECT GUI Setup and Execute a SPECT Protocol Acquisition Histogram Reconstruction Setup and Execute a SPECT Workflow Workflow Setup Running a Workflow Setup and Execute a SPECT/CT Workflow Workflow Setup Running a Workflow   Continue to the course assessment to complete the course. The graphic user interface (GUI) allows you to monitor the status of and move the SPECT detectors as well as configure additional isotopes for SPECT acquisition. The graphic user interface (GUI) displays the collimators installed on each detector as well as the distance of each detector from its home position. When using the Collimator Setup Wizard, you must identify the collimator installed on each detector, which is displayed in the status bar of the GUI. To access the SPECT motion controls, select Panels > System > MM Motion Control.  You can move the SPECT heads toward (IN arrow) or away from (OUT arrow) the gantry's isocenter.  Additionally, you can move the detectors to any arbitrary position away from their home position by typing a millimeter value in the field and clicking Move Now, and you can move the detectors to their home position by clicking Home. IAW automatically configures 8 SPECT isotopes for quick use in protocols. To configure additional SPECT isotopes and their half-life, select Tools > Options, and click SPECT > Isotope. Click Add to create additional isotopes (including the half-life and branching fraction), and click OK to save the settings. The Inveon Multimodality offers the flexibility of performing sequential SPECT and CT scans in order to create an anatomical and functional image pair. A SPECT/CT workflow combines any number of CT and SPECT acquisitions, histograms, and reconstructions in a seamless workflow. Since the SPECT detectors are mounted coaxially on the same stage as the CT source and detector, the position of the specimen is the same for both modalities (in bed position #2). The transformation matrix is applied to the CT image to co-register it to the SPECT image. Once you have created a new workflow, you can drag and drop protocols from the System Navigator to the Workflow panel. Optionally, you can click Add to select protocols for the workflow. Make certain to add the protocols in the correct order; i.e. acquisition before histogram or reconstruction. Workflow setup Workflow setup Checklist Checklist TitleChecklist TypeChecklist ContentStep 1HTMLAfter you have opened a new workflow protocol, drag and drop the desired acquisition and reconstruction protocols into the workflow. Step 2HTMLOptionally, you can click Add or Remove to edit the workflow. Note that the order cannot be changed once they're in the workflow. Step 3HTMLClick Save, and name the workflow. Video: Setting up a SPECT/CT Workflow Video: Setting up a SPECT/CT Workflow   Protocols added to a workflow are run sequentially in the order they are placed in the workflow setup. SPECT acquisition data are saved in listmode (*.lst) files, SPECT histogrammed data are stored in sinograms (*.scn), and SPECT reconstructed images are *.img files. Carefully confirm the runtime parameters before starting the workflow. Click the checklist below to learn how to run a workflow. Running a SPECT/CT Workflow Running a SPECT/CT Workflow Checklist TitleChecklist TypeChecklist ContentStep 1HTMLMake certain microQ is running on the host computer prior to any SPECT histogram or reconstruction.Step 2HTMLConfirm that COBRA is online.Step 3HTML Laser align the object in the center of the FOV for the first modality acquisition protocol in the workflow.Step 4HTMLType a name for the dataset in the Dataset Name field (example: DDMMYY_objectID_study).  Step 5HTMLClick Setup. Step 6HTMLDefine the runtime parameters for each protocol. Refer to the User Manual for more details. Step 7HTMLInput a SPECT/CT transformation matrix file. Ignore this step if using this workflow to generate a transformation matrix.  Step 8HTMLClick Start Workflow. Step 9HTMLRefer to the ASIPro or IRW user manuals to view image data. Note that sinogram data can only be viewed in ASIPro. The System Navigator panel in IAW allows you to easily organize protocols, datasets, and workflows. To create a new protocol, 1. Create a new study folder, if necessary. 2. Open the study folder, and then open its Protocols subfolder. 3. Right-click the folder that corresponds to the protocol you want to create (Acquisition or Reconstruction), click New Protocol, and choose the modality of the protocol you wish to create. The SPECT acquisition protocol allows you to configure four different types of scans: SPECT scan, normalization, planar, and calibration.  To perform a SPECT scan, you must uninstall the bore tunnel to prevent any collision. In addition, you must laser align the specimen before initiating a SPECT scan.  The SPECT acquisition can be acquired from one or both detectors with different radii of rotations. More information on the acquisition parameters can be found in the User Manual. Click on the checklist below for steps to create a SPECT acquisition protocol. Acquisition Protocol Setup Acquisition Protocol Setup Checklist TitleChecklist TypeChecklist ContentStep 1HTMLPrior to any SPECT acquisition, make certain you remove the bore tunnel if it is installed.Step 2HTMLUse the Collimator Setup Wizard to change the collimators as needed. Refer to the User Manual for detailed instructions. Step 3HTMLCreate a new SPECT acquisition protocol.  Right-click an Acquisitions folder and select New Protocol > SPECT. Step 4HTMLModify the SPECT acquisition parameters for your study. For detailed information on acquisition parameters, refer to the User Manual.Step 5HTMLMake certain the number of projections divides evenly into the number of subsets (refer to the reconstruction protocol to setup the number of subsets). Step 6HTMLUse the following steps to configure the First Step Acquisition Time and Number of Projections:                1) Set First Step Acquisition Time to 10 seconds.              2) Click Scout View.              3) Note the Total Counts for each detector.              4) Use the formula to calculate the First Step Acquisition Time. Step 7HTMLClick Save. The SPECT histogram protocol determines how SPECT listmode data is histogrammed. The data is binned into a sinogram for each time frame and each gate bin.  SPECT histogram parameters are described in further detail in the User Manual. Click on the checklist below for steps to create a SPECT histogram protocol. Histogram Protocol Setup Histogram Protocol Setup Checklist TitleChecklist TypeChecklist ContentStep 1HTMLCreate a new SPECT histogram protocol in a study or folder of your choice. Step 2HTMLSelect the Acquisition Mode from the drop-down list.Step 3HTMLModify the SPECT histogram parameters for your study. For detailed information on histogram parameters, refer to the User Manual.Step 4HTMLOptionally, enable gating. Refer to the User Manual as well as BioVet® User Manual for more details. Note that SPECT gating is retrospective gating and must be set up prior to executing the SPECT acquisition. Step 5HTMLClick Save.Step 6HTMLOptionally, you can run the protocol immediately without first adding it to a workflow if you already have the input SPECT sinogram availabale. Click Submit, and select the Input Listmode File. A SPECT reconstruction protocol determines how SPECT sinogram files are to be reconstructed into images, including what algorithms to use, and what corrections apply to the reconstruction. SPECT reconstruction parameters are described in further detail in the User Manual. Click on the checklist below for steps to create a SPECT reconstruction protocol. Reconstruction Protocol Setup Reconstruction Protocol Setup Checklist TitleChecklist TypeChecklist ContentStep 1HTMLCreate a new SPECT reconstruction protocol in a study or folder of your choice. Step 2HTMLModify the SPECT reconstruction parameters for your study. Refer to the User Manual for more details.Step 3HTMLClick Save.Step 4HTMLOptionally, if you want to run the protocol immediately, click Submit, and select the Sinogram Input File, Normalization Input File, and optional Attenuation Input File. After protocols are configured, they are typically added to a workflow to be run in the workflow execution, although histogram and reconstruction protocols can be run independently if you already have listmode data or a sinogram to reconstruct. Like PET workflows, the SPECT acquisition generates listmode data, the histogram converts listmode data into a sinogram, and the reconstruction uses the sinogram to reconstruct images. To create a workflow, right-click the Workflows folder and click New Workflow. In the following order, a complete SPECT workflow includes an acquisition, a histogram, and a reconstruction. Once you have created a new workflow, you can drag and drop protocols from the System Navigator to the Workflow panel. Optionally, you can click Add to select protocols for the workflow. Make certain to add the protocols in the correct order; i.e. acquisition before histogram or reconstruction. Click on the checklist below for steps to build a SPECT workflow. SPECT Workflow Setup SPECT Workflow Setup Checklist TitleChecklist TypeChecklist ContentStep 1HTML After you have opened a new workflow protocol, drag and drop the desired acquisition and reconstruction protocols into the workflow. Step 2HTMLOptionally, you can click Add or Remove to edit the workflow. Note that the order cannot be changed once they're in the workflow. Step 3HTMLClick Save, and name the workflow. Protocols added to a workflow are run sequentially in the order they are placed in the workflow setup. SPECT acquisition data are saved in listmode (*.lst) files, SPECT histogrammed data are stored in sinograms (*.scn), and SPECT reconstructed images are *.img files. Carefully confirm the runtime parameters before starting the workflow. Click the checklist below to learn how to run a workflow. Steps to Running a Workflow Steps to Running a Workflow Checklist TitleChecklist TypeChecklist ContentStep 1HTMLMake certain microQ is running on the local host workstation prior to any SPECT histogram or reconstruction.Step 2HTMLLaser align the object in the center of the PET field of view. Refer to the User Manual or the laser alignment portion of the System Overview section.Step 3HTMLType a name for the dataset in the Dataset Name field (example: DDMMYY_objectID_study). Step 4HTMLClick Setup. Step 5HTMLDefine the runtime parameters for each protocol. Refer to the User Manual for more details.Step 6HTMLClick Start Workflow. Step 7HTMLRefer to ASIPro and IRW User Manuals to view image data. Note that PET sinogram data can only be viewed in ASIPro, not IRW.