MR Neuro 3D BOLD - Numaris X JobAid

MR Neuro 3D - BOLD MR Neuro 3D workflow is used to read BOLD image data. The BOLD data is used as in- put to calculate fMRI Maps, which graphically display stimulation areas in the brain.  Note: Load up to four BOLD Acquisitions, a Field Map, and select an anatomical scan out of the available anatomical datasets acquired. 1. From the Patient Worklist, load the appropriate data set into the MR Neuro 3D Workflow a. Examination correctly mapped: double click to load b. Manual mapping required: right-click the examination and select Open With > MR Neurology. @ Open Ctrl+O @ Open with Favorites View as Read-Only with Suggested Batch Open MR Breast Assign Workflow MR BreVis Group Studies MR Cardiac Analysis * Batch Assign Workflow MR Neuro 3D Cancel Workflow MR Neurology Search Patient with DICOM Q/R MR Oncology 2. MR Neuro 3D Reading: Preconfigured Steps a. Alignment: compensate for patient motion between referenced anatomical scan and BOLD Acquisition and Diffusion Tensor Data, or to allow for Reading of data of different studies. b. Image Selection: select structural data sets (underneath functional data) and if the Field map should be displayed. c. fMRI: evaluate the dataset of a BOLD acquisition with a focus on map fusion d. Time Course Evaluation: perform a quality check of a single BOLD acquisition e. Export: prepare data for radiology assessments or third-party software. Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 SIEMENS Master Template: EFF Date 22 Aug 17 | HOOD/HILS HOOD05162002647849 Healthineers Jobaid: Effective Date: 02/07/2020 | HOOD/HILS HOOD05162003063264 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 3. Alignment: automatically or manually align the loaded BOLD acquisition and the diffusion tensor data with a chosen reference data set. Image alignment is required to correct the misalignments between different acquisitions. e.g., compensates for patient motion or changing frames of a reference due to patient repositioning. a. Reference Volume: 3D Volume sequence automatically selected b. Overview Layout i. Click a BOLD or Tensor acquisition in the Case Navigator fMRI_03, Course x * 7/18/1982 M 1232334 MR Neuro 3D + fMRI 03, Course Siemens Healthcare MF 1232334 MR Neuro 3D Reading # *7/18/1982, M, 26Y Verit MR B15 CURRENT | CURRENT HE Alignment 7/18/2008 t1_mpr_ns_sag_p2_iso | ep2d_diff_mddw_20_p2_TENSOR Reference Volume t1_mpr_ns_sag_p2_iso.latest latest | latest STUDY ID 1 Targets 2:03:46 PM 13 IMA~88 | 27 IMAn.a. FRM n.a. ep2d_pace_dynt_moco ep2d_pace_dynt_moco Overview Layout t1_spc_ns_sag_iso.latest t2_spc_ns_sag_p2_da-fl_iso.latest -A ep2d_diff_mddw_20_p2_TENSOR latest 5 cm Alignment Overview TI 900.0 Palettes Advanced Perfusion TR 1900.0 TE 2.5 TP SP L6.7 | SP L6 MPR FUSION : p2 M/ND/NORM 246*25 Sa Blend A1/IR 4.49 195 *tf13d1_ns / 9 39 Contrast agent c. Check images for correct alignment: if you detect a misalignment, perform the following steps. Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 2 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 d. Align the Images i. Auto Alignment Icon: Automatically adjusts alignment Auto Align ii. Visual Alignment Icon: Manually align images 1. Select Visual Alignment Icon: resets alignment to perform image alignment manually. Visua 2. Rotation Wheel with center pivot in the middle Align displayed a. Left click and move the pivot to the required position b. Click and grab the rotation wheel to rotate the fMRI image until images are aligned fMRI 03, Course × M * 7/18/1982 M 1232334 M H MR Neuro 3D fMRI_03, Course Siemens Healthcare MR 1232334 *7/18/1982, M. 26Y Verio MR B15V Targets CURRENT | CURRENT HFS 7/18/2008 ep2d_pace_dynt_moco t1 mpr_ns_sag_p2_iso | ep2d_diff_mddw.201p2 TENSOR GOR ep2d_pace_dynt_moco latest | latest (1_spc_ns_sag_iso.latest STUDY ID 1 2:03:46 PM 2_spc_ns_sag_p2_da-fl_iso.latest 13 IMA~88 | 27 IMAna: FRM n.a ep2d_diff_mddw_20_p2_TENSOR.latest A Alignment Overview Palettes 5 cm Advanced Perfusion Blend TI 900.0 TR 1900.0 TE 2.5 TP O SP L6.7 | SP L6.7 MPR FUSION : p2 M/ND/NORM 246*256 Auto Align Visual Align A1/IR 931 956 *tf13d1 ns / 9 149 398 Image Selection Contrast agent Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 3 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 4. Palettes: select a color palette for the BOLD acquisition and define the Blend value 5. Blend Value: adjust slider to change color intensity of overlay (or) leave default selection (Optional) Alignment Overview Palettes Advanced Perfusion Blend 6. Color LUT: select colors applied to Target and Reference images (or) use “Default” selections. a. Lower Right Corner Menu > select Color LUT for each i. Target: BOLD acquisition ii. Reference: Anatomy R fMRI_03, Course X MF * 7/18/1982 M 1232334 MP .................................................................................... .......................................................................................................... H MR Neuro 3D fMRI 03, Course Siemens Healthcare MR 1232334 *7/18/1982, M. 26Y Verio Targets CURRENT | CURRENT MR B15V HFS 7/18/2008 ep2d_pace_dynt_moco t1_mpr_ns_sag_p2_iso | act MoCoSeries ep2d_pace_dynt_moco latest | latest/Phase_01 t1_spc_ns_sag_iso latest STUDY ID 1 2:03:46 PM t2_spc_ns_sag_p2_da-fl_iso.latest 13 IMA~88 | 4 IMAn.a. FRM n.a. ep2d_diff_mddw_20_p2_TENSOR.latest Alignment Overview Palettes Advanced Perfusion 5cm L Blend : 48.00% TR 1900.0 TE 2.5 SP L6.7 | SP L6. 7 MPR FUSION : p2 M/ND/NORM 246+35¢ Auto Align Advanced Perfusion A1/IR MR Color LUT *tf13d1 ns / 9 C Target Image Selection Edges Reset Windowing agent Reference Grayscale Heart fMRI_03, Course Siemens Healthcare MR Findings Navigator *7/18/1982, M. 26Y verlo Hot Iron MR B15V CURRENT | CURRENT Name Value 7/18/2008 Hot Metal New t1_mpr_ns_sag_p2_iso | act MoCoSeries latest | latest/Phase_01 Inverted Grayscale STUDY ID 1 2:03:46 PM Perfusion 13 IMAn.a. FRM n.a. | 4 IMAn.a. FRM n.a. Thal Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 4 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 7. Image Selection Layout 1) Image Segments 2) Structure Selection List 3) Field Map List SIEMENS Q MR_NEURO_3D_FMRI_ALIGNMENT_ . 1/1/1979 (35Y) M 34567 MR_TaskflowC ARCardiacAn .. MR Neuro 3D PHLA MR_NEURO_3D_FMRI_ALIGNMENT_798 Institution Name MR_NEURO_3D_FMRI_ALIGNMENT_798 Institut Institution Name MR Neuro 3D +1/1/1979, M, 28Y TrioTim 34567 TrioTim MR B15 "1/1/1979, M, 28Y MR B15 HFS CURRENT HFS Alignment 3_11_mpr_ns_sag_p2_iso 3_11_mpr_ns_sag_p2_iso latest latest Image Selection -> Current.MR_FUSION_STRUC .. > Current.MR_FUSION_STRUCTURE (1) STUDY ID 1 STUDY ID 1 Structure 10/23/2007 10/23/2007 11:49:28 AM 11:49:28 AM 3_11_mpr_ns_sag_p2_iso.latest 21 INAn.a 21 IMA n.a. Field Map No Field Map IMRI AD WN Tractography T1 900.0 TI 900.0 TR 1900.0 TR 1900.0 Time Course Evaluation TE 2.5 SL 1.0 TE 2.5 MPR FUSION : p2 M/N SPC 1.0 Export MPR FUSION : p2 M/ND/NORM AMAR Sag>Cor(-35)>Tra(4) ALAR Cor-Sag(34)>Tra(-10) Remaining Images 959 "t13di_ns / 9 459 "t13di_ns / 9 459 . . .. ALF MR_NEURO_3D_FMRI_ALIGNMENT_798 Institution Name MR_NEURO_3D_FMRI_ALIGNMENT_798 Institution Name 34567 34567 "1/1/1979, M, 28Y Trio Tim MR B15 "1/1/1979, M, 28Y TrioTim MR B15 Findings Navigator CURRENT HFS CURRENT HFS 3_11_mpr_ns_sag_p2_iso 3_11_mpr_ns_sag_p2_iso latest latest Name Value Source MO -> Current.MR_FUSION_STRUCTURE .>> Current.MR_FUSION_STRUCTURE STUDY ID 1 STUDY ID 1 10/23/2007 10/23/2007 11:49:28 AM 11:49:28 AM Tools SLULALALALA & Mion Fullest Grigies Line's TI 900.0 TR 1900.0 TR 1900.0 TE 2.5 SL 1.0 TE 2.5 MPR FUSION : p2 M/ND/NORM SPC 1.0 VRT : p2 MIND/NORM Snapchat ist Engert ALAR Tra>Sag(-8)>Cor(6) SP A23.5 959 ALAR "t1301_ns / 9 459 "t13di_ns / 9 Cop Tra(39)>Sag(31) 4:01 PM 8. Image Selection: select the structural data set shown underneath the functional data set. a. Image Selection step is active b. Case Navigator: select Structure images from list c. Select Field Map from list (e.g., Field Map only available if no image alignment was performed) d. Select Diffusion Tensor Data from the list Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 5 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 9. fMRI Layout 1) MPR Image Segments (displays fused statistical maps) 2) VRT Segment 3) Blend Slider 4) Slider to adjust color saturation 5) Selection list for color LUT’s for non-active and active areas 6) Buttons for color settings 7) List of BOLD acquisitions Server: SYLABVIAV820 Administrator fMRI_03, Course . 7/18/1982 M 1232334 MR Neuro 3D Q + MPR MPR IMRI_03, Course Siemens Healthcare MR IMRI_03, Course Siemens Healthcare MR MRI 1232334 .7/18/1982. M. 26Y Verio 1232334 MR B15V .7/18/1982, M. 26Y CURRENT HFS CURRENT Function 7/18/2008 7/18/2008 (7) - >[7] ep2d_pace_dynt_moco t1 mor ns sag p2 t1 mor ns sag_p2 latest Latest -- > Current MREFUS -- > Current.MRLF STUDY O 1 STUDY O 1 2:03:46 PM 2:03:46 PM 13 IMA-54 13 IMAna. FRMGE (6) O Primary Individual Uniform @ Secondary R (5) - none Hot Metal 5cm (4) - LA -15.00 -4.00 4.00 15.00 TI 900.0 TI 900.0 TR 1900.0 TE 25 TP O TR 1900.0 SP R27.5 TE 2.5 :: 00.33 mm max 00.31 deg max MPR FUSION : p2 Mit 246.256 MPR FUSION :p2) 546-256 AM/R 951 AM/R (3) Blend "3di_na / 9 449 Contrast agent Contrast agent IMRI_03, Course MPR Siemens Healthcare MR 1232334 Findings Navigator "7/18/1982, M. 26Y Verio CURRENT MR B15V HFS Name Value Source 7/18/2008 t1_mpr_ns_sag_p2_iso Istest -> Current.MR_FUSION_STR STUDY O 1 2:03:46 PM 13 IMAn.a. FRM n.a Tools Synch Full Text Hide Lines F Hide Reset Graphics Timepol TP O SP H34.8 MPR FUSION : p2 MIND/NORM 246.256 Edit Snapshot Print Layout Export Image Stack AMAR Tra 951 449 Contrast agens VRT 10. fMRI (Reading Statistical Maps): displays both anatomical images and the computed statistical maps, in 3D (MPR) and 3D (VRT) fused view for evaluation. a. fMRI Step is active b. Show/Hide statistical maps (functional data): check boxes to turn display On/Off in image segments. Map On: indicated by “eye” icon Map On: indicated by “white box” fMR fMRI Function Function [7] ep2d_pace_dynt_moco [7] ep2d_pace_dynt_moco Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 6 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 11. Determine Color Settings a. Select a Statistical Map (Functional sequence) b. Select Color Palette c. Individual Icon: select a color LUT from the selection list d. Uniform Icon: select and apply a color LUT to all statistical maps e. Highlight Icon: highlights the selected map as the Primary LUT (Highlight) Individual Uniform Highlight 12. Link/Unlink Icon: select to link positive and negative LUT Threshold sliders 13. Blend Sliders: move blend slider to determine the blend value hone Hot Metal 15.00 -4.00 4.00 15.00 14. Right Lower Corner Menu > Function > select fMRI :: 00.33 mm max 00.31 deg max Experiment (e.g., Right Foot, Right Hand, etc.) > Blend Function (Activation) a. Function Properties i. Interpolation: default ON ii. Clustering Size: default 20 iii. Select OK Function Properties Structure Bounding Box ep2d_pace_dynt_moco Function Function Properties ? × ep2d_pace_dynt_moco none Hot Metal -15.00 -4.00 4.00 15.00 All Activation Maps Interpolation Clustering Size 20 OK Default Cancel Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 7 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 15. Editing VRT Segment: use tools to improve the display of the active regions in a 3D view. a. Upper Left Corner Menu i. Select 3D Reference Point and click on a position in the VRT segment 1. Aligns MPR images to 3D point determined in the VRT segment ii. Clip Planes: turn on Clip Planes to display an area inside the VRT volume Zoom/Pan HPR 3D Reference Point Rotate urse -O- Windowing 6Y Home Position Clip Plane ISO Show Clip Plane Graphics Split Plane FUSION_STRUd Change Orientation Feet to Head Fit to Segment Reset Clip Plane Head to Feet 2:03:46 PM Anterior to Posterior Posterior to Anterior Left to Right Right to Left HPR fMRI_03, Course Siemens Healthcare MR 7/18/1982, M, 26Y Verio MR B15V CURRENT HFS 7/18/2008 t1 mpr_ns_sag_p2_iso latest .. > Current.MR FUSION_STRUCTURE STUDY ID 1 2:03:46 PM RA 10cm TI 900.0 TR 1900.0 TE 2.5 5 2.3. VRT : p2 MIND/NORM TP O SP P29.6 A1/IR 246*256 *tf13d1_ns / 9 Cor> Tra(39)>Sag(31) VRT Gallery Structure4 Contrast agent Bounding Box Function Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 8 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 16. Time Course Evaluation: perform a quality check for each BOLD acquisition to determine if a specific BOLD acquisition is suitable for reading (e.g., no extensive patient movements occurred) a. Time Course Evaluation Step is active b. Case Navigator Icon > select Function > BOLD Sequence i. VOI Icon: draw a volume of interest around an active area -OR- ii. Voxel Icon: use voxel of interest in an active area iii. Lower Right Segment: mean signal time course for selected voxels is displayed showing the corresponding active and rest phases. c. Right-click volume (VOI or Voxel) > select Shrink to Activation d. Delete All Icon: select to delete previously created VOI or Voxel of Interest MR Neuro 3D + Blend Time Course Evaluation Function VOI Voxel Delete All ep2d_pace_dynt_moco ep2d_pace_dynt_moco H [7] ep2d_pace_dynt_moco fMRI 03, Course Siemens Healthcare MR 1232334 7/18/1982. M. 26Y Verio MR B15V CURRENT HFS O Primary 7/18/2008 t1_mpr_ns_sag/p2_iso VOI1 Individual Uniform Highlight Secondary latest -- > Current MR TIMECOURSE BASE STUDY ID 1 2:03:46 PM. 13 IMA~53 none Hot Metal A -15.00 -4.00 4.00 15.00 5cm Blend L TI 900.0 TR 1900.0 TE 2.5 TP 0 SP R29.1 VOI MPR FUSION : p2 M/ND/NORM 246 256 Voxel Delete All A1/IR Sag 951 "tf13d1 _ns / 9 449 Contrast agent Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 9 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 17. Offline BOLD: generate statistical maps, and if necessary, apply motion correction to BOLD images. a. Image Area: shows available BOLD Data (Preferably the motion-corrected images, if available) b. Lower Right Segment: shows stimuli information of used preset. c. Motion Correction (Translation/Rotation) of BOLD data displayed for all phases 23 40 Range Selection Stimuli_1 Ignored Tx Ty TZ Translation 1.0 (Max 0.59 mm) -0.0 1.0 Rx Ry Rz -1.0 Rotation (Max 0.29 deg) 0.0 -1.0 10 20 30 40 50 4D Timepoints 18. Case Navigator > select parameters to be calculated a. Protocol Editor: define contrasts and detailed parameters 19. Select MR Neuro 3D Calculation > select Offline BOLD a. BOLD Data is loaded b. Read Images and Navigate through Phases: Middle Slider (yellow) in lower right segment to navigate through phases. i. Position of slider defines phase in image segment currently shown 23 40 Range Selection Stimuli_1 Ignored Tx Ty Tz Translation 1.0 (Max 0.59 mm) -1.0 Rx Ry Rz 1.0 Rotation (Max 0.29 deg) 10.0 1.0 4D Timepoints Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 10 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 c. Determine Start and End phase for Calculation i. Position Left (Green) ii. Position Right (Red) Sliders 40 Range Selection Stimuli_1 Ignored Tx Ty Tz Translation 1.0 (Max 0.59 mm) 0.0 -- 1.0 Rx Ry Rz Rotation -1.0 (Max 0.29 deg) +0.0 -1.0 30 40 50 60 4D Timepoints d. Case Navigator> select a Preset from the list e. Click Protocol Editor Icon to Create a New Preset i. Apply required parameters for calculation f. No Motion-corrected BOLD data available > select check boxes for Motion Correction, and Spatial Filter (if needed) g. GLM Evaluation: check box to calculate one statistical map for each defined contrast Select Preset default Motion Correction[ Spatial Filter 2.0 mm GLM Evaluation v h. Click Start BOLD Evaluation Icon to start BOLD calculation 20. Save Results Save and Send: Results are stored on the system and sent to your archive Save and Pause: Results are stored on the system Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 11 of 12 Job Aid | MR Neuro 3D BOLD - Numaris X Effective Date: 2/7/2020| HOOD05162003063264 Please note that the learning material is for training purposes only! For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (herein- after collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator's Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Copyright © Siemens Healthcare GmbH 2018 ………………………………………………………… Siemens Healthineers Headquarters Siemens Healthcare GmbH Henkestr. 127 91052 Erlangen, Germany Telephone: +49 9131 84-0 siemens.com/healthineers Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018 Page 12 of 12