xSPECT Quant Sensitivity/Cross Calibration Procedure

xSPECT Quant Sensitivity/Cross Calibration Procedure Step by Step Description: This Step by Step procedure will guide the user in performing sensitivity and cross calibration procedures necessary for the accurate quantification of xSPECT studies. What You Will Need: Co57 xSPECT Calibration/Peaking Source Kit (for use with LEHR and LPHR collimators) Note: If your scanner has Automatic Quality Control (AQC), your kit will not have a peaking source. The name of the kit is Co57 xSPECT Calibration Source Kit. SIEMENS 1 2 3 Se75 xSPECT Calibration/Peaking Source Kit (for use with MELP collimators) SIEMENS ===== SPECT Quem - 2 3 Cross Calibration Source (peaking and calibration sources for respective clinical isotope to be calibrated) SIEMENS Healthineers www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 1 of 6 Performing the xSPECT Sensitivity Procedure: Description: In order to enable xSPECT Quant acquisitions, the system must be calibrated with the following calibration procedure. Siemens recommends these calibrations to be performed once a month. Overview of Procedure Tuning and Peaking Tuning is a calibration that adjusts the gains of the PMTs Peaking shifts the analyzer window that it is centered around the actual energy peak as detected by the camera. Sensitivity Calibration The sensitivity calibration measures the difference between the system’s ability to detect the radioactivity and the true amount of radioactivity using a precision source and collimator. Cross Calibration The cross calibration measures dose calibrator bias using a measured point source and collimator. This step is optional but recommended as it enables unbiased SUV quantification. Steps to Perform Procedure Sensitivity Calibration or Cross Calibration 1. Home the system and remove the collimators 2. Mount the peaking source. a. Unscrew vial holder cap from the end of the integrated source holder b. Loosen thumb screw on the top of peaking source. c. Slide peaking source over end of the source holder. d. Remove the calibration source from the room e. If performing the Cross Calibration, place the peaking source in the holder. 3. On the syngo MI Acquisition Workplace, register or select the patient and launch the Sensitivity Calibration workflow or Cross Calibration workflow that is located in the Calibration category. 4. Peak the system a. Camera Parameters Tab b. Select the appropriate camera preset from the pulldown menu. Sensitivity Calibration Se75 – SC-Se75-LME-NMG • Co57 – SC-Co57-NMG • Cross Calibration Tc99m – SC-Tc99m-NMG In111 – SC-In111-NMG I 123 SC-I123-NMG – *Lu177 – SC-Lu177-208 NMG c. Go to the Analyzer Tab d. Peak the camera. e. Put away peaking source f. Install the collimators SIEMENS Healthineers .. www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 2 of 6 5. Sensitivity Calibration: If this is the first time that you are using this source, you need to next enter the Precision Source Registration. a. Select the Analyzer tab b. Select the Source Management tab. c. Select Entry Type from pull down d. Label Menu: Enter source serial number e. Assay: i. Enter dose information from system apparent activity on source label. ii. Assay Date iii. Make sure correct isotope is selected on the Camera Parameters tab. iv. Save. Your registered source will show in the Registered Labels pull down menu. a Parameters |Stop Conditions |Source Mgmt Registered Labels: New Item Entry Type: 75 Selenium Dose Calibrator 75 Selenium Label: 57 Cobalt Assay. Dose: 0 MBq 8/ 4/2016 Save Delete f. Navigate to the Series Information Tab and go to the Calibration Source menu. Select the precision source you are using. Summary |Series Information Camera Parameters Stop Conditi Series: Technologist Reading Physician: Referring Physician Organ Calibration Source Isotope: Label 75 Selenium 13-483 Dose: 0 MBq &/ 4/2016 12:00:00 AM 6. Cross Calibration: If this is the first time you are using a particular dose calibrator, you need to next enter the Dose Calibrator Registration. a. Go back to the Source Management tab. b. Enter the dose calibrator name in the Label field c. Make sure the correct isotope is selected on the Camera Parameters tab. d. Save Camera Parameters Stop Conditions Source Mgmt Registered Labels: New Item Entry Type: Dose Calibrator Label: DC11 Assay Dose: 0 MBq 8/ 4/2016 Save Delete SIEMENS Healthineers www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 3 of 6 e. Navigate to the Series Information Tab and go to the Calibration Source menu. Select the dose calibrator used to measure the point source. 7. Install the Calibration source. a. Screw the source to the end of the integrated source holder b. Active element is contained in the sphere at the pointed end of the calibration source. c. Position the active element over the center of the detectors. d. If you are preforming the Cross Calibration, install the point of the isotope into the end of the integrated source holder. e. Position the activity in the vial over the center of the detectors. 8. Acquire the Sensitivity/Cross Calibration a. Press Prepare Acquisition System initiates motion to the position the detectors with a 10 cm source to collimator distance. b. Press Start Acquires an uncorrected image for both detectors simultaneously. Proceeds to Sensitivity Calculation activity. Camera Parameters Camera Parameters Supine Supine 1024 X 1024 1024 X 1024 1.0 1.0 SC-Tc99m-NMG Both Detectors Done SC-Tc99m-NMG Both Detectors Done Prepare Acquisition Prepare Acquisition = SIEMENS Healthineers www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 4 of 6 9. Sensitivity Calculation Activity a. Processes the Calibration data. b. Review the following: Patient Collimator Isotope Presets Crystal Thickness c. Photopeak menu Photopeak Measured sensitivity results are displayed If results acceptable Accept These Calibrations and Make Them Current If results not acceptable Reject These Calibrations and Use Existing Set 20160610_Bay8_SensCalib_MELP_Se75. 16.08.10-17:40:33-DST-1.3.12.2.1107.5.6.1 1008 Ejle View Template Workflow Activities Help O A Sensitivity Calibration Processing Sensitivity Calibration Patient 20160510_Bay6_SensCalib_MELP_Se75 Collmator. Medium-Energy, Low-Penetration Isotope 75 Selenium Preset SC.Se75-LME-NMG Photopeak Crystal 3/8" Concussion 75 Selenium 133 kev 75 Selenium 133 key 75 Selenium 269 key etector 2 Sensitivity - Nominat 86.8 Sensitivity - Nominal 86.8 CPS/MBq Sensitivity . Measured 94.0 CPSMBG Sensitivity - Measured 93.4 CPS/MB4 Deviation from Nominal: 8.3 Deviation from Nominal 7,7 % Reject These Calbrations and Use Existing Set Accept These Calibrations and Make Them Current d. Click Complete Image data and Sensitivity Calculation save screen are saved to the patient database • e. Remove calibration source f. Retract integrated source holder. 10. Review the Sensitivity Calibration Dashboard. a. A calibration dashboard is available on the Series Information tab to show available calibration for collimators and presents. Series Information |Camera Parameters Stop Conditions |Sourc Series: Technologist Reading Physician: Referring Physician: Organ: Calibration Source Isotope: Label: 99m Technetium Date: Time: Dose: 0 MBq 8/ 4/2016 12:00:00 AM Available Calibrations Date Colli ... Preset Source ID 10-Jun-16 LPHR SC-Co57-NMG N1-641 10-Jun-16 LPHR SC-Tc99m-NMG N1-641 10-Jun-16 LPHR SC-1123-NMG N1-641 10-Jun-16 MELP SC-Se75-LME-NMG M6-483 10-Jun-16 MELP SC-1123-NMG M6-483 10-Jun-16 MELP SC-Lu177-208-NMG M6-483 10-Jun-16 MELP SC-In111-NMG Me 102 M6-483 25-May-16 LEHR SC-Co57-NMG N1-641 25-May-16 LEHR SC-Tc99m-NMG N1-641 SIEMENS Healthineers www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 5 of 6 *xSPECT Quant 177Lu is not commercially available in some countries, including the US. 177Lu is not currently recognized by the US FDA as being safe and effective, and Siemens does not make any claims regarding its use. Due to regulatory reasons, its future availability cannot be guaranteed. Please contact your local Siemens organization for further details. SIEMENS Healthineers .. www.usa.siemens.com/healthcare HRT# HOOD05162002580375 Effective Date: 3/27/2017 Page 6 of 6