Parametric Imaging: Biograph Acquisition Protocols Online Training USA

Continue Continue Continue Continue Parametric Pt2 Parametric Imaging: Biograph Acquisition Protocols Online Training This online training will provide an in-depth overview of both the standard and fully-automated acquisition protocols. Compare the two different acquisition protocols supported by the Multiparametric PET Suite 1 Apply TrueD to patient images as a form of retrospective QC 4 Demonstrate the benefits of Direct Reconstruction compared to Image-Based Reconstruction 3 Practice performing a Basic Automated Workflow 2 Master Template HOOD05162003052540 | Effective Date: 26-Nov-2019 Welcome Audio Filename: oltintroslide Para-metric Imaging: Biograph Acquisition Protocols Online Training (Pause) This online training will provide an in-depth overview of both the standard and fully-automated acquisition protocols. (Pause) By the end of this training, you will be able to: Compare the two different acquisition protocols supported by the FlowMotion Multi-para-metric pet Suite Practice performing a Basic Automated Workflow Demonstrate the benefits of Direct Reconstruction compared to Image-Based Reconstruction Apply True-D to patient images as a form of retro-spective QC Acquisition Protocols No change to current FDG (Fludeoxyglucose)-PET acquisition Standard PET images still generated for SUVs User-generated IF (Input Function) as a CSV file (Blood sampling, probes, population-based) IF auto-scaled to WB dynamic PET data Analysis completely automated and self-contained Standard PET images still generated for SUVs Image-based IF automatically generated Longer acquisition time compared to clinical FDG-PET acquisition See the Resources Tab to view the full prescribing information. WB Dynamic WB Dynamic Heart Standard Fully-Automated Acquisition Protocols Audio Filename: acquisitionprotocols Two different acquisition protocols are supported enabling both clinical and research uses. There is the standard acquisition protocol that requires no change to the current F-D-G, or fludeoxyglucose (pronounced flew-d-oxy-glucose), pet acquisition. The patient is injected with F-D-G in the uptake room and rests quietly during the uptake period. Then a multipass dynamic wholebody continuous bed motion scan is acquired for 10 to 20 minutes. The standard pet images are still generated for S-U-Vs, or standard uptake values . It does require user generated input function to be imported. This information consists of blood sampling, probes or can be population based. The input function is auto-scaled to WB dynamic pet data. The other method of acquisition is the fully automated acquisition protocol. The patient is positioned on the bed with the heart in the field of view. The patient is injected with the FDG on the bed at the start of the acquisition. A single bed list mode acquisition is acquired over the heart for approximately 6 minutes. Following that, a multipass dynamic whole body continuous bed motion acquisition is performed for approximately 40 minutes. The analysis is completely automated and self contained. There are still standard pet images that generate S-U-Vs. The image based input function is automatically generated. It does require a longer acquisition time compared to clinical FDG-pet acquisition. See the Resources Tab to view the full prescribing information for fludeoxyglucose (pronounced flew-d-oxy-glucose). Fully-Automated Acquisition Overview Single Bed List Mode FlowMotion Whole Body Dynamic Started at injection Up to 100 dynamic frames or 125 when combined with WB Cardiac Region (Merged Dynamic Series) Passes can have up to 4 variable bed speed regions Up to 6 contiguous passes for Patlak Recon, minimum of 3 Up to 25 passes for image-based modeling Fully-Automated Acquisition Overview Audio Filename: fullyautomatedacquisition Automated acquisition is protocol-based and uses the same user interface as clinical imaging. First the topogram (pronounced toe-po-gram) and the C-T scan are acquired. Following the C-T acquisition, a single bed list mode pet acquisition in the cardiac region is obtained. This is started at the injection of F-D-G and up to 100 dynamic frames are acquired. Combined with up to 25 frames of the whole body cardiac region, the merged dynamic series may equal 125 frames. Features of the Multiparametric PET Suite Select the tab arrows to learn more about the different features available in the FlowMotion Multiparametric PET suite. FlowMotion syngo’s ALPHA Direct Reconstruction TrueD syngo.via Features of the Multiparametric PET Suite Audio Filename: featuresofmultiparasuite Select the tab arrows to learn more about the different features available in the FlowMotion Multiparametric PET suite. Audio Filename: flowmotion Adding continuous bed motion, like with FlowMotion, you will get a more complete picture of the uptake and when it occurs. In this example, every bed pass provides a wholebody image at different stages of the uptake of the isotope. This way, the tracer uptake in tumor areas can be measured over time. Select the X to return to the Features of the Multi-para-metric pet Suite page. Audio Filename: syngoalpha Obtaining arterial blood samples over time is an operator-intensive process with a small risk for the patient. syngo’s (pronounced sing-go’s) alpha, or Automatic Landmark Parsing of Human Anatomy tools uses the C-T image to find anatomical landmarks. One in the center of left ventricle, which is a sphere V-O-I and the other in the thoracic aorta, which is a cylinder V-O-I. The arterial input function is obtained automatically by measuring the uptake in a region of interest located in the descending aorta or the left ventricle without the need for an invasive measurement. Audio Filename: directreconstruction Current solutions for research using parametric imaging create parametric images using reconstructed activity concentration images. With FlowMotion multiparametric imaging, images are reconstructed directly from the raw data, which allows for reduced noise and more efficient workflow. Audio Filename: trued The True-D application runs on the Acquisition Workplace and can be used to assess the automated V-O-I placement, patient motion and input function. The True-D application allows you to move V-O-Is to account for patient motion as well as create new V-O-Is and input functions, if needed. Audio Filename: syngovia syngo.via (pronounced sing-go-vee-ah) is our unique platform to view and interpret images. It automates the end to end parametric workflow for preparation, reading and reporting. It also allows readers to view and measure standard uptake value, metabolic rate and distribution volume images simultaneously with dedicated layouts. It supports multiple quantitative units as well, such as milli-grams per minute per 100 milli-liters. syngo.via Support multiple quantitative units (e.g. mg/min/100 mL) Allows readers to view and measure SUV, MR, and DV images simultaneously with dedicated layouts Automates the end-to-end parametric workflow for preparation, reading, and reporting syngo.via is our unique platform to view and interpret images. syngo.via: Images Courtesy of Yale University – New Haven, CT, USA TrueD TrueD allows the user to: Move VOIs to account for patient motion Create new VOIs and input functions TrueD allows for the assessment of: Automated VOI Placement Patient Motion Input Function Images Courtesy of Yale University – New Haven, CT, USA Direct Reconstruction Image-Based Reconstruction Direct Reconstruction Current solutions for research create parametric images using reconstructed activity concentration images. FlowMotion Multiparametric reconstructs directly from the raw data, allowing for: Reduced noise More efficient workflow Images Courtesy of Yale University – New Haven, CT, USA Arterial Input Function (AIF) is obtained automatically by measuring the uptake in a region of interest located in the descending aorta or the left ventricle without the need for an invasive measurement. Activity (Bq/mL) Time (min) syngo’s Automatic Landmark Parsing of Human Anatomy (ALPHA) tools use the CT image to find anatomical landmarks Center of Left Ventricle (Sphere VOI) Thoracic Aorta (Cylinder VOI) syngo’s ALPHA Images Courtesy of University of Geneva - Geneva, Switzerland FlowMotion Images Courtesy of Keio Gijyuku University Hospital - Tokyo, Japan Basic Automated Workflow Basic Automated Workflow FlowMotion MulitParametric PET Suite is an optional feature on the Biograph mCT (VG70) and Biograph Vision. With the necessary licensing configured, the WholebodyDynamicCBM Patlak protocol will be available. For this example, we have already acquired the CT Topogram and CT Spiral scan. For our automatic workflow, the injection is performed with the patient on the table a few seconds after the start of the PET acquisition. On the routine subtask card, the scan duration defaults to 6 minutes. This can be changed if required. The number of beds defaults to 1 and cannot be changed. On the Recon subtask card, the parameters can be adapted to meet your needs. On the replay subtask card, you can set the number of frames and times you require. The default settings are depicted here. For the second recon job, the replay subtask card is configured as a static replay with 1 bed, a 60 second delay, and 300 second duration Once the PET Input function has been acquired, the next step is to acquire the wholebody dynamic data. For this example, three ranges have been created with a total of 10 passes. The first reconstruction is set as a PET wholebody dynamic. You have the option to change the reconstruction parameters to meet your needs. The second reconstruction is set as a PET dynamic input region. The reconstruction parameters for this recon cannot be modified. The input region is the tail of the input region and is linked to the bolus of the Input function. The third reconstruction will sum passes 6 -10 and serve as the reconstruction job for SUV analysis. The reconstruction parameters can be adapted to fit your needs. The 4th reconstruction will serve as the Patlak reconstruction. The number of passes has to be at least 3 but no more than 6. Notice the additional Patlak subtask card. The Patlak subtask card renders the input function options . Indications and Important Safety Information Indications and Usage Fludeoxyglucose F 18 Injection (18F FDG) is indicated for positron emission tomography (PET) imaging in the following settings: Oncology: For assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities, or in patient with an existing diagnosis of cancer Cardiology: For the identification of left ventricular myocardium with residual glucose metabolism and reversible loss of systolic function in patients with coronary artery disease and left ventricular dysfunction, when used together with myocardial perfusion imaging Neurology: For the identification of regions of abnormal glucose metabolism associated with foci of epileptic seizures Important Safety Information Radiation Risk: Radiation-emitting products, including 18F FDG, may increase the risk for cancer, especially in pediatric patients. Use the smallest dose necessary for imaging and ensure safe handling to protect the patient and health care worker Blood Glucose Abnormalities: In the oncology and neurology setting, suboptimal imaging may occur in patients with inadequately regulated blood glucose levels. In these patients, consider medical therapy and laboratory testing to assure at least two days of normoglycemia prior to 18F FDG Adverse Reactions: Hypersensitivity reactions with pruritus, edema and rash have been reported; have emergency resuscitation equipment and personnel immediately available ​Dosage Forms and Strengths Multiple-dose 30 mL and 50 mL glass vial containing 0.74 to 7.40 GBq/mL (20 to 200 mCi/mL) of Fludeoxyglucose F 18 Injection and 4.5 mg of sodium chloride with 0.1 to 0.5% w/w ethanol as a stabilizer (approximately 15 to 50 mL volume) for intravenous administration. See the Resources Tab to view the full prescribing information. Indications and Important Safety Information Audio Filename: indicationssafetyinformation The following information describes Fludeoxyglucose (pronounced flew-d-oxy-glucose) F 18 Injection for intravenous use. Fludeoxyglucose (pronounced flew-d-oxy-glucose) F18 Injection (or 18F F-D-G) is indicated for positron emission tomography (pet) imaging in the following settings: In oncology for assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities or in patients with an existing diagnosis of cancer. In cardiology for the identification of left ventricular my-o-car-d-um with residual glucose metabolism and reversible loss of systolic function in patients with coronary artery disease and left ventricular dysfunction, when used together with myocardial perfusion imaging. In neurology for the identification of regions of abnormal glucose metabolism associated with foci (pronounced foe-sigh) of epileptic seizures. Important Safety Information about Fludeoxyglucose (pronounced flew-d-oxy-glucose) F 18 Injection: Radiation Risk: Radiation-emitting products, including 18F FDG, may increase the risk for cancer, especially in pediatric patients. Use the smallest dose necessary for imaging and ensure safe handling to protect the patient and health care worker. Blood Glucose Abnormalities: In the oncology and neurology setting, sub-optimal imaging may occur in patients with inadequately regulated blood glucose levels. In these patients, consider medical therapy and laboratory testing to assure at least two days of normo-glycemia prior to 18F FDG. Adverse Reactions: Hyper-sensitivity reactions with prur-itus, e-dee-ma and rash have been reported; have emergency re-sus-citation equipment and personnel immediately available. ​Dosage Forms and Strengths for Fludeoxyglucose (pronounced flew-d-oxy-glucose) F 18 Injection: Multiple-dose 30 milli-Liters and 50 milli-Liters glass vial containing 0.74 to 7.40 giga-beck-er-els per milli-liter (20 to 200 milli-curry per milli-liter) of Fludeoxyglucose F 18 Injection and 4.5 milli-grams of sodium chloride with 0.1 to 0.5 percent weight per weight ethanol as a stabilizer (approximately 15 to 50 milli-Liter volume) for intravenous administration. Select the Resources Tab to view the full prescribing information. Apply TrueD to patient images as a form of retrospective QC Demonstrate the benefits of Direct Reconstruction compared to Image-Based Reconstruction Practice performing a Basic Automated Workflow Compare the two different acquisition protocols supported by the FlowMotion Multiparametric PET Suite Course Review Congratulations. You have completed the Parametric Imaging: Biograph Acquisition Protocols Online Training course. Select the objectives listed below to review the material before proceeding to the final assessment. 1 1 1 2 2 2 3 3 3 4 4 4 Course Review Apply TrueD to patient images as a form of retrospective QC TrueD allows the user to assess the automated VOI placement, patient motion, and input function move VOIs to account for patient motion create new VOIs and input functions Demonstrate the benefits of Direct Reconstruction compared to Image-Based Reconstruction Image-Based Reconstruction Create parametric images using reconstructed activity concentration images Direct Reconstruction Images are reconstructed directly from the raw data Allows for reduced noise and more efficient workflow Practice performing a Basic Automated Workflow FlowMotion MultiParametric PET Suite is an optional feature on the Biograph mCT (VG70) and Biograph Vision For the automatic workflow, the injection is performed with the patient on the table a few seconds after the start of the PET acquisition On the routine subtask card, the scan duration defaults to six minutes The user has the option to change the reconstruction parameters as needed For the Patlak Reconstruction the number of passes has to be at least three but no more than six Compare the two different acquisition protocols supported by the FlowMotion Multiparametric PET Suite Standard Acquisition Protocol FDG Injection in Uptake Room Multi-pass dynamic WB CBM (10-30 minutes) Standard PET Images still generated for SUVs User-generated input function as a CSV file IF auto-scaled to WB dynamic PET data Fully-Automated Acquisition Protocol Analysis completely automated and self-contained FDG Injection on bed at start of acquisition Single bed list mode acquisition over heart (6 minutes) Multi-pass dynamic WB CBM (40 minutes) Image-based IF automatically generated Longer acquisition time compared to clinical FDG-PET acquisition Please note that the learning material is for training purposes only! For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator's Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Copyright © Siemens Healthcare GmbH 2020 Siemens Healthineers Headquarters\Siemens Healthcare GmbH\Henkestr. 127\ 91052 Erlangen, Germany\Telephone: +49 9131 84-0\siemens-healthineers.com Disclaimer Disclaimer Assessment This assessment will test your retention of the presented content. A passing score of 80% or higher is required to complete the course and earn your certificate. You may repeat the assessment as many times as needed. Start Assessment It involves injecting the patient in the uptake room before the start of the acquisition It requires a minimum of 60 minutes for uptake The protocol has a longer acquisition time than standard clinical FDG-PET imaging Which of the following is true of a fully-automated acquisition protocol? Question 1 of 5 Select the best answer. Multiple Choice Question Incorrect The patient is injected on the bed at the start of the acquisition. Incorrect The scan begins immediately after the patient is injected. Correct Utilizes the raw PET data Results in reduced noise Provides a more efficient workflow Utilizes reconstructed activity concentration images Which of the following is not true of direct reconstruction of parametric images? Question 2 of 5 Select the best answer. Multiple Choice Question Incorrect Direct reconstruction provides a more efficient workflow. Incorrect Direct reconstruction results in reduced noise. Incorrect Correct Direct reconstruction utilizes the raw PET data. uses the CT image to find anatomical landmarks. can be used to assess patient motion and input function. cannot assess automated VOI placement. The TrueD application… Question 3 of 5 Select the best answer. Multiple Choice Question Correct Incorrect TrueD does assess automated VOI placement. Correct syngo’s ALPHA allows this. Allows readers to view and measure SUV, MR, and DV images Allows readers to view and measure images one at a time Supports one quantitative unit How does syngo.via assist with viewing and interpreting images? Question 4 of 5 Select the best answer. Multiple Choice Question Incorrect syngo.via supports multiple quantitative units Incorrect syngo.via allows users to view and measure images simultaneously with dedicated layouts Correct Approximately six minutes Ten minutes Exactly five minutes Two to three minutes For the fully-automated acquisition protocol the patient is placed on the bed with their heart in the field of view. How long does the acquisition over the heart last? Question 5 of 5 Select the best answer. Multiple Choice Question Incorrect The acquisition of the heart is longer than three minutes Incorrect The acquisition of the heart is longer than five minutes Incorrect The acquisition of the heart is shorter than 10 minutes Correct Review Review Retry Assessment Results %Results.ScorePercent%% %Results.PassPercent%% Continue YOUR SCORE: PASSING SCORE: Assessment Results You did not pass the course. Take time to review the assessment then select Retry to continue. Congratulations. You passed the course. Exit To access your Certificate of Completion, select the Launch button drop down on the course overview page. You can also access the certificate from your PEPconnect transcript. You have completed the Parametric Imaging: Biograph Acquisition Protocols Online Training. Completion HOOD05162003091997 | Effective Date: 15-JUN-2020 Fludeoxyglucose F 18 Full Prescribing Information 1.1 Welcome 1.2 Acquisition Protocols 1.3 Fully-Automated Acquisition Overview 1.4 Features of the Multiparametric PET Suite 1.5 Basic Automated Workflow 1.6 Indications and Important Safety Information 1.7 Course Review 1.8 Disclaimer 1.9 Assessment 1.16 Completion