syngo.via MR Tissue4D Job Aid

SIEMENS Healthineers MR Tissue4D Job Aid Template Effective Date: 27 May 2019 | HOOD05162003010284 Job Aid Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Table of Contents Overview 3 AHL MR Tissue4D Q + Concentration Curve ROI1 / Multi1 Min / Max: 0.17 AU/0:36 AU 0.40 Concentration MR Tissue4D Analysis Mean/SD: 0.28 AU/0.05 AU Pharmacokinetic Modeling Area: 0.37 cm2 4 0.248 : 0.30 Qualitative Model 5 Motion Correction Alignment RON 0.20 Processing Tofts Model 7 Reading RA 0.10 ROI Ellipse VOI Pixel Lens Tofts Model Fit 9 Sphere Export to 0.00 Viewing 50 10 150 200 250 Time(Sec) Contrast Agent Calculation 11 0 Ktrans Finding Legenc Show Ktrans Kep Ve ¡AUC chi2 ROI1 0.259 0.994 0.261 0.267 0.056 ... Input Data 12 Findings AHL AHL Findings ROI1 / Multi1 ROI1 / Multi1 Steps 13 Min / Max: 0.52 AU/1.37 AU Min / Max: 0.18 AU/0.34 AU Finding 2 Mean/SD: 1.05 AU/0.25 AU Mean/SD: 0.27 AU/0.04 AU Multi1 0.37 c ... || 5.82 Area: 0.37 cm2 Area: 0.37 cm2 0.44 Reading Tissue4D C3 19 OROIN ORON Findings 20 RA RA Properties 21 Tools L Synch Alion Hide Hide Lines Reset Text Graphics Timepoi .. T1 Settings 22 Kep AUC Edit Snapshot Print Export Undo Redo References 23 Layout Image Image 1:07 PM 2 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Overview With MR Tissue4D, you can generate parametric maps that reveal information on the vascularization and the permeability of the contrast enhancement in the tissues. For the parametric maps and pharmacokinetic modeling, 2 models can be selected: • Qualitative • Tofts The MR Tissue4D functionality is available in 2 workflows: • MR Tissue4D • MR Prostate workflow The parametric maps can be read and analyzed together with the morphological images. For analyses, the standard measurement tools and dedicated Tissue4D tools are available. 3 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Pharmacokinetic Modeling The MRI signal intensity is converted into contrast agent concentrations, called MRI modeling, based on O MRI Kinetic the relaxivity (property of each contrast agent), modeling modeling Pharmacokinetic native T1 of the tissue, and the relative enhancement MRI signal Contrast Agent model intensity concentration of the tissue after contrast agent administration. parameters (e.g., K trans) After the Concentration Curve is obtained, the T1, AIF... Qualitative maps can be generated. These maps Relaxivity… correspond to the Qualitative model, which analyses this curve voxel-by-voxel, and produces one output map for each of the fitted parameters. Qualitative maps, Parameter maps, Alternatively, instead of the Qualitative model, the e.g., wash in e.g., Ktrans Tofts model can be applied, which describes the pharmacokinetic behavior of contrast agent slowly leaking from the vessels into the Extravascular, Extracellular Space. In this process, a population-based AIF has to be selected. 4 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Qualitative Model (1/2) The Qualitative model applies MRI modeling in order to transform the MRI signal into concentration values of the Contrast Agent. O MRI modeling MRI signal Contrast Agent intensity concentration • This MRI model requires the native T1 of the tissue before contrast arrival, as well as information regarding the relaxivity of the tissue to this particular T1, Relaxivity… Contrast Agent (each Contrast Agent has a different relaxivity) and the Signal Intensity after Contrast Agent • The Signal Intensity after Contrast Agent is taken from the scanned images • The relaxivity of each Contrast Agent is taken from the properties of the Qualitative maps, e.g., workflow wash in • The native T1 before Contrast Agent injection is a tissue property. Either a constant value is assumed, or the T1 relaxivity is measured with dedicated image acquisitions. 5 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Qualitative Model (2/2) Concentration Curve 0.05 Concentration • The Concentration Curve displays the Concentration of the Contrast Agent 0.04 in every voxel. The curve is fitted into 3 tangent lines 0.03 • Baseline – Time before contrast enhancement 0.02 • Wash In – Enhancement in the tissue due to contrast agent arrival 0.01 • Wash Out – End of wash-in until the end of measurement 0.00 50 100 150 200 250 Time(Sec) W-In W-Out AT PE TTP ¡AUC 0.044 0.003 0.172 0.042 0.736 0.023 Concentration Curve 0.60 Concentration PEI • Arrival Time (AT) – Point in time when contrast enhancement starts TTP • Wash In – Slope of the fitted line between AT and end of wash-in 0.45 • Wash Out – Slope of the fitted line between start of wash-out and end of 0.30 measurement AT • Time To Peak (TTP) – Time from arrival time to end of wash-in 0.15 • Peak Enhancement Intensity (PEI) – Maximum concentration of the contrast enhancement in wash-out 0.00 0 50 100 1 50 200 250 Timer Sec) Finding Show //-Out TTP AT ¡AUC • Initial Area Under the Curve (iAUC) – Initial area under the curve from egend WV-In PEI ROI1 0.939 -0.011 0.525 0.172 0.562 0.387 arrival time to 60 sec 6 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Tofts Model (1/2) The MR Tissue4D workflow uses the standard Tofts model, which is a one compartment 1) kinetic model, corresponding to the Extravascular, Extracellular Space (EES). The Bolus injection standard Tofts model assumes that the contrast agent leaves the vessel and is equally dispersed in the EES, with minimum redistribution to the vascular space. extra- blood Extravascular cellular Plasma Extracellular space C (t) Ktrans Space (EES) (whole Ce(t) Ve • The influx rate between plasma blood and EES is conditioned on blood flow, vessel body) Vp permeability and vessel surface area Renal Tissue C.(t) • The contribution of contrast agent present in the intravascular space is considered excretion negligible and is ignored (i.e., Vp=0) 2) After reaching an equilibrium, the Contrast Cell Agent is transferred back into the blood plasma. This redistribution rate back to blood plasma is represented by Kep and excreted via Capillary (Vp ) K trans the urinary tract. kep EES (Ve ) (Extravascular, Cell Once in the EES, gadolinium does not enter the Extracellular cells. Space) 1) Source. Tofts, PS. MAGNETOM Flash 3/2010 7 2) Vandana Mohana, Yoshihisa Shinagawa, Gerardo Hermosillo; Expanded Pharmacokinetic model for Effective Date: 07 Oct 2021| HOOD05162003228316 population studies in Breast MRI (SIEMENS MEDICAL SOLUTIONS, USA) Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Tofts Model (2/2) • K trans – Transfer constant of Contrast Agent (CA) between blood plasma and Extravascular, Extracellular Space (EES) Kinetic Kep – Reflux constant, depicting the transfer rate of contrast agent (CA) modeling • Pharmacokinetic returning to blood vessels Contrast Agent model Ve – Fractional volume of EES concentration parameters (e.g., • iAUC – Initial area under the curve (60 sec) AIF... K trans) • • chi2 – Degree of error of the fit • The values like T1 relaxivity and the Contrast Agent enhancement are also used for the calculation of the Tofts model Parameter maps, Ve – Fractional volume of Extravascular, Extracellular Space. Ve is always between 0 and 1. E.g., a value e.g., Ktrans • of 0.5 means that 50% of the EES is occupied by cells, and the remaining 50% is the space between the cells where the Contrast Agent usually lies • Ve is an important factor, because gadolinium does not enter the cells, thus its concentration on the EES depends on its value • Kep is related to Ve and Ktrans with kep defined as Ktrans/Ve 8 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Tofts Model Fit (1/2) The physiological relationship can be modeled using the equation described by Paul Tofts in his 0.15 1991 publication. It contains known parameters and parameters that will be estimated (also called - Ktran=0.30 min-1 .... Ktran=0. 10 min --- Ktran=0.03 min-1 free parameters). In our case, we know the Cp from the AIF (Arterial Input Function), the Ct from 0.10 the concentration curve of the acquired DCE data, and t-τ (or time to onset) from the arrival time Ct (mM) (also taken from our acquired data). This means that the free parameters are K trans and Ve 0.05 . 1) ........... . Bolus injection 0.00 Equation 1 (Standard Tofts Model): 0 2 4 6 8 10 time / min extra- blood Extravascular cellular Plasma Extracellular space Co(t) Ktrans Space (EES) (whole Ce(t) Ve C.(t) = Ktrans f Cp(T)e-(Ktrans /ve)(t-t'dt body) 0.25 Vp Renal Tissue C.(t) 0.20 excretion ................................ - V .= 40 % ...... V .= 20% --- V .= 10% $ 0.15 We also know that when Ktrans and Ve are found, this equation will result in a curve that has a 0. 10 Ct (mM) specific shape and height. For example, the model simulations above show that Ktrans mainly .................... 0.05 controls the initial slope of the curve (the higher K trans the steeper the initial slope). On the other , 0.00 hand, when keeping Ktrans fixed, the height of the curve and shape after initial onset is controlled by 2 4 6 8 10 O time / min Ve and Kep. Knowing this, the system tries to find the value of Ktrans and Ve that results in a curve that is the closest possible to the acquired data. This is what is called a model fit. 1) Source: Tofts, PS. MAGNETOM Flash 3/2010 9 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Tofts Model Fit (2/2) An AIF (Arterial Input Function) is used during the Bolus D. 15 1 injection - Ktram=0.30 min -1 ................... Koran=0. 10 min-1 modeling. There are 3 AIF models which need to be --- Ktram=0.03 min-1 blood 0.10 extra- Extravascular Plasma Extracellular selected by the user: cellular space C. (t) Ktrans Space (EES) Ce(t Ve Ct (mM) (whole 0.05 Fast Based on Orton et al. body) Vp ........ ......... - 0.00 P .--------- Intermediate Based on Parker et al. Renal Tissue C.(t) 0 2 - excretion time / min Slow Based on Weimann et al.* - Equation 1 (Standard Tofts Model): 0.25 C, (t) = Ktrans [ Cp(T)e-(Ktrans /veKt->dt 0.20 - V .= 40% ...... V .= 20% --- V .= 10% Ct (mM) The quality of the fit can be evaluated visually by comparing how close the acquired data curve is to the model line ----------- 0.05 on the concentration curve graph. The chi2 (X2 ) value also gives an impression of how close these 2 curves are. 0.00 2 4 6 10 O 00- time / min During a model fit, the system uses known parameters like the concentration of CA in the tissue (Ct ), and on blood plasma (Cp ), and it estimates the unknown or free values, Ktrans and Ve . After giving a value to K trans and Ve the resulting model curve will have a specific shape and height that will be , compared with the curve of the acquired data. The system will keep estimating different values for the free parameters until it finds the value that results in a curve that is the closest to the measured concentration curve. 1) Source: Tofts, PS. MAGNETOM Flash 3/2010 10 * See slide 23 for full citation Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Contrast Agent Calculation • The Field Strength is taken from the DICOM Header • Relaxivity and molarity are defined per Contrast Agent and delivered by the Contrast Agent manufacturers • Dose is defined per Contrast Agent in Tissue4D properties • The volume is taken from Contrast/Bolus Volume The system checks if all the following fields are filled in the DICOM Header: • Magnetic Field Strength (0018,0087) • Contrast/Bolus Agent (0018,0010) • And/or Contrast/Bolus Volume (0018,1041) If the volume information is not found in the DICOM Header, it is calculated from • The dose (mmol/kg) • The molarity of the Contrast Agent (mmol/ml) • The weight of the patient in kg, which is written in the DICOM Header The volume is then calculated as follows: Volume = (dose x weight) / molarity 11 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Input Data t2_tse_tra_p3_352 02:57 Morphology Measured T1 T1 mapping__ B1 Map_for_T1_mapping 00:09 1 T1 Map_vibe_tra MapIt Images for T1 mapping B1Map_for_T1_mapping 00:09 00:50 require the same 1 measurement parameters T1 Map_vibe_tra 00:50 (FOV, slice position etc.) as the 1 Or Pixelwise T1 dynamic series. Pª t1_vibe_tra_flip_2deg 00:55 t1_vibe_tra_flip_2deg 00:55 2 2 t1_vibe_tra_flip_15deg 00:55 VIBE with 2 flip Please also see slide 21 for a ª t1_vibe_tra_flip_15deg angles 00:55 2 configuration of the input 2 dynamic data roles. t1_vibe_tra_p4_dyn 04:44 Constant T1 – Value t1_twist_tra_p2_dyn Or entered in the Tissue4D 06:25 properties t1_vibe-twist_dixon_tra_dyn_p4 Or 04:05 t1_vibe-grasp_fs_tra_224 Or 05:00 GRASP 12 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Steps The complete workflow consists of several steps. In each step there are some tasks for the user to carry out. MR Tissue4D AHL Concentration Curve ROI1 / Multi1 Concentration MR Tissue4D Analysis Min / Max: 0.17 AU/0:36 AU 0.40 Mean/SD: 0.28 AU/0.05 AU 1. Motion correction Area: 0.37 cm2 Os 0.248 1 0.30 2. Alignment Motion Correction 3. Processing Alignment 0.20 Processing RA 4. Reading Reading 0.10 CSV ROI Ellipse VOI Pixel Lens Sphere CSV 0.00 Viewing 50 100 150 200 250 Time(Sec) Finding Legend ¡AUC Ktrans Show Ktrans Kep Ve chi2 O RO11 0.259 0.994 0.261 0.267 0.056 Findings AHL AHL ROI1 / Multi1 ROI1 / Multi1 Findings Min / Max: 0.52 AU/1.37 AU Min / Max: 0.18 AU/0 34 AU Finding 2 Mean/SD: 1.05 AU/0.25 AU Mean/SD: 0.27 AU/0.04 AU Multi1 0.37 c ... | 5.82 Area: 0.37 cm2 0.44 Area: 0.37 cm2 OROIN DROIT RA RA Tools L Synch Align Custom Hide Hide Lines Reset Graphics Timepoi ... AUC Edit Snapshot Print Export Undo Redo Layout Image Image 1:07 PM 13 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Motion Correction Step In the Motion Correction step, the possible movement of the patient during the dynamic scan will be corrected, so that all the pixels throughout the whole dynamics are in the same position. Motion Correction uses Elastic Registration. The reference for the registration is selected by the system automatically. The system selects the point approximately in the middle of the enhancement uptake of the processing volume. MR Tissue4D Analysis Motion Correction Os All phases Blending 0 100% Motion Correction Reference phase Excluding / Blending 100% Current phase IIIIIII including phases Set Ac Toggle Include Include Include Reference Images All Phases Phase Rest All Set As Toggle Exclude Exclude Reference Images Phase Rest All MR Tissue4D Analysis Os Toggle between motion corrected / Motion Correction non-motion corrected images Blending O 100% Set a new reference phase Set As Exclude Exclude Reference Images Phase Rest All 14 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Alignment Step In the Alignment step, all the morphological images and the Pre-contrast images are aligned to the same position of the motion correction reference phase, so that all pixels from the different images are in the same position. • Alignment uses Elastic Registration • All images listed under the pull-down menus should be verified for correct position Alignment Alignment Morphology To Dynamic Morphology To Dynamic Morphology T2_TSE_TRA_REG Morphology T2_TSE_TRA Blending Blending Toggle Images to the original images, 100% 100% O O Align Toggle Align Toggle Images Images the alignment can be modified. Pre-contrast To Dynamic Pre-contrast To Dynamic Flip Angle 10 Flip Angle 10 Blending Blending 0 100% 100% O Align Toggle Align Toggle Images Images 15 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Processing Step (1/2) In the Processing step, the parameters for calculation MR Tissue4D Q + Volume 328.60 cm3 Concentration Curve Min / Max: 0.00 /763.00 Mean/SD: 190.32/124.92 0.50 Concentration of the parametric maps can be changed or modified. Processing 1) Recalculation is required 0.40 Model Tofts 0.30 AlF Intermediate • Verify the following: Contrast Agent Gadovist 0.20 Protocol Pixelwise 11 • Volume of processing 0.10 Selection of the processing model: Reading • 0:00 150 225 Time(ses) ) Qualitative / Tofts Findings Ktrans Kep 0.18 0.391 Ve AUC 0.214 chi2 0.461 0.042 • The protocol type and Contrast Agent used • Verify the AIF modeling and select the one 0.98 -0.061 with the lowest chi² (X2 ) value (lowest fitting error) Tools MR Tissue4D Ch Volume 328.60 cm3 . Min / Max: 0.00 /763.00 Custom Hide Hide Lines Repet Mean/SD: 190.32 /124.92 Graphics Timepoi ... • The recalculation of parametric maps with different Motion Correction Edit Snapchot Print Export Undo WASH-IN Image settings Layout Alignment 11:26 AM Processing Model Qualitative Contrast Agent Gadovist Protocol Constant T1 Settings R Arrival 37.56 sec Falculate Reading Findings 16 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Processing Step (2/2) Processing MR Tissue4D Processing Settings ? X In the Settings, you can select Recalculation is required Settings the following: Contrast Agent Model Qualitative • Selection of the Contrast Agent Magnevist Field Strength BT Contrast Agent Tofts • Contrast Volume Qualitative Gadovist model Relaxivity 5.1 I/mmo ... Prohance Protocol Constant T1 Settings Multihance Molarity mmol/ ... • Depending on the LL Dotarem Dose 0.09375 mmol/ ... presettings in properties, Omniscan Arrival 10.31 sec Calculate Time Maps Optimark Volume 7.5 ml the T1 settings are shown (Assumed T1, pixelwise T1, Protocol · Qualitative Tofts Processing Assumed T1 2000 measured T1) ms Model Tofts Threshold 20 • Assumed constant T1, if AIF Intermediate Selection of AIF model constant T1 has been Contrast Agent Fast Intermediate (for Tofts model only) selected Protocol Slow OK Cancel • Threshold Arrival 10.31 sec Calculate Time Maps Please also see page 21 for the configuration of the input data roles. 17 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Reading Step The generated parametric maps can be read in the following workflows: • MR Tissue4D workflow in the Reading step • MR Prostate workflow in the MR Prostate Reading step. The corresponding _dyn_ layout needs to be selected. The maps and the morphological images can be evaluated at the same time; the standard tools like 3D Reference Point can be used for finding the position. For documenting the results, the standard measurement tools and dedicated Tissue 4D dedicated tools are available. AHL Concentration Curve AHL Reading Concentration Curve ROI! / Mult1 0.40 Concentration ROI1 / Multi 1 Concentration Mean/'S @: 0 28 AU1 05 AU Area 0 66 cm2 0.30 goes + CSV [+ 0.20 ROI Ellipse VOI Pixel Lens Export to Sphere CSV RA 0.10 0.15 0.00 1.00 1 50 200 250 100 150 200 230 Finding Legend Show ktrans Kep Ve VAUC chi2 WASHIN Finding Legend Show WW.In W-Out TIP AT PEI ROM 0.259 0 994 0 251 0:267 0.056 ROM 0.939 0.011 0 525 D.172 0.552 0.337 AHL AHL AHL AHL ROIt / Multi1 ROI1 / Multit ROIT / Multi1 ROIt / Multi1 Mini Mais 0 08 ALIIDIDSIAL May May: 0-17 ALL/ D 62:44 Area 0:37 cm2 Area 0:37 cm2 Are: 0 66 cm2 Area: 0 66 cm2 OROIN Wish. Our 18 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Reading Tissue4D In the MR Prostate Reading step, select MR Prostate AHL AHL AHL a layout that includes Dyn. MR Prostate Reading 2.1 Single Learn Biopsy Click Segments Support The maps can be evaluated at the same Prostate time as all other scanned images of the Lesions RA RA RA prostate. Prostate MTDF20_RemoteAdmin Private Layouts The standard tools like 3D Reference Public Layouts Point can be used for finding the Morph & Morph 3D Diff Diff & Dun Morph & Diff & position. For documenting the results, Spectro HAR AHL Distance Line Concentration Curve the standard measurement tools and Concentration Marker IT 2.00 Morph & MPR 3D Compare Meancury Diff & Dyn & Spectro 2x2 Volume 0. 0 Arrow dedicated Tissue4D tools are available. 0.52 Min / Mas Mean/SD. Angle ingle Sum 5 33 >> Advanced Close 12 Voxels Text T VOT4D VOI Sphere 1.00 Export P-Map to CSV RP RA Tools = Synch Alian Full Text Hide Hide Lines Reset 0.00 Graphics Timepoi ... 0 50 100 150 200 250 Time(Sec) WASHIN Finding Legend Show VW-In WV-Out TTP AT PEI iAUC Edit Snapshot Print Export Undo Redo VOI1 V 2.642 -0.112 0.172 0.842 Layout Image Image 1:12 PM 19 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Findings The findings are saved as AHL MR Tissue4D C. + Concentration Curve ROI1 / Multi1 MR Tissue4D Analysis Min / Max: 0.17 AU/0:36 AU Concentration 0.40 snapshots and can be sent to Mean/SD: 0.28 AU/0.05 AU Area: 0.37 cm2 0.248 PACS. 0.30 Motion Correction Alignment ORON 0.20 The result values can also be Processing Reading RA exported as a CSV file. 0.10 csy ROI Ellipse VOI Pixel Lens Export to Sphere 0.00 Viewing O 0 50 100 150 200 250 Time(Sec) Finding Legend Show Ktrans Ktrans Kep Ve iAUC chi2 ROI1 0.259 0.994 0.261 0.267 0.056 Findings AHL AHL Findings ROI1 / Multi1 RO11 / Multi1 Min / Max: 0.52 AU/1.37 AU Min / Max: 0.18 AU/0 34 AU Finding 2 Mean/SD: 1.05 AU/0.25 AU Mean/SD: 0.27 AU/0.04 AU Multi1 0.37 c ... Q 5.82 Area: 0.37 cm2 Area: 0.37 cm2 0.44 PRON RA RA Tools Synch Align Custom Hide Hide Lines Reset Text Graphics Timepoi ... Kep AUC Edit Snapshot Print Export Undo Redo KU Image Image 1:07 PM 20 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers Properties The Settings icon in the top of the Tissue4D workflow opens the Properties. Here you can set the default settings for Preprocessing that takes place during the workflow assignment. Data definition of the image data that MR Tissue4D Properties ? × Processing: will be used for the processing: Data Def. Preprocessing Alignment Processing Parametric Map • Default Contrast Agent • Morphology Morphology Pre-Contrast Dynamic • Contrast Agent table Series Descriptions Series Descriptions Series Descriptions Pre-Contrast (for T1 mapping) t2_tra PreContrast t1_vibe • t2_tse_tra flip t1_twist • T1 settings dyn • Dynamic T1_vibe*_W MR Tissue4D Properties ? X MR Tissue4D Properties Preprocessing: Motion correction registration Data Def. Preprocessing Alignment Processing Parametric Map Data Def. Preprocessing Alignment Processing Parametric Map • Contrast Agent Alignment and registration Registration • Restore Morphology on Dynamic Elastic Magnevist(Default) Field Strength 0.0 + TO 0.04 + Gadovist Pharmacokinetic model selection Pre-Contrast on Dynamic Elastic Prohance 0 -11 • Multihance Relaxivity 4 /mmol/s Dotarem • Volume of interest settings Dynamic MotionCorrection Omniscan Molarity 0.5 mmol/ml Pharmacokinetic Model Antimark H Dose 0.1 mmol/kg + Add Remove Set As Model Qualitative Default Protocol . Qualitative Tofts Volume of Interest Assumed T1 2000 ms Type Ellipsoid Threshold 20 Center x 50 % Diameter x 50 9 50 ¢ 9 50 + 0% 50% 50 OK Cancel OK Cancel 21 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers T1 Settings MR Tissue4D Properties ? X Data Def. Preprocessing Alignment Processing Parametric Map Measured T1 B1Map_for_T1_mapping 00:09 Protocol Qualitative . Tofts 1 Protocol Type Measured T1 T1 Map_vibe_tra 00:50 Series Description T1_image Threshold 20 Pixelwise T1 t1_vibe_tra_flip_2deg 00:55 Protocol Qualitative . Tofts 2 t1_vibe_tra_flip_15deg 00:55 Protocol Type Pixelwise T1 Constant T1 2 Threshold Pixelwise T1 Measured T1 Constant T1 Protocol · Qualitative Tofts Assumed T1 2000 ms Threshold 20 22 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 MR Tissue4D SIEMENS Healthineers References To learn more, you can consult the following articles: 1. Tofts, P.F., T1-weighted DCE Imaging Concepts: Modelling, Acquisition and Analysis. MAGNETOM Flash 3/2010. 2. Orton MR, d'Arcy JA, Walker-Samuel S, Hawkes DJ, Atkinson D, Collins DJ, Leach MO. Phys Med Biol. 2008 Mar 7;53(5):1225-39. Computationally efficient vascular input function models for quantitative kinetic modelling using DCE-MRI. 3. Parker GJ, Roberts C, Macdonald A, Buonaccorsi GA, Cheung S, Buckley DL, Jackson A, Watson Y, Davies K, Jayson GC. Magn Reson Med. 2006 Nov;56(5):993-1000. Experimentally-derived functional form for a population- averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. 4. Weinmann H, Laniado M, Mutzel W. Physiol Chem Phys Med NMR. 1984 ;6(2):167-72. Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. 5. Rohrer, M, Bauer H, Mintorovitch J, Requart M, Weinmann HJ Invest Radiol 2005; 40: 715-724 Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. 23 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021 SIEMENS Healthineers Please note that the learning material is for training purposes only. For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Please note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. © Siemens Healthcare GmbH 2021 Siemens Healthineers Headquarters Siemens Healthcare GmbH Henkestr. 127 91052 Erlangen, Germany Telephone: +49 9131 84-0 siemens-healthineers.com 24 Effective Date: 07 Oct 2021| HOOD05162003228316 Unrestricted © Siemens Healthineers, 2021